Midazolam binds to stereospecific benzodiazepinenreceptors on the postsynaptic GABA neuron at various sites within the CNS, including limbic system and reticular formation.

Enhancement of the inhibitory effect of GABA on neuronal excitability results by increased neuronal membrane permeability to Cl ions, which results in hyperpolarisation and stabilisation.

Therapeutic Category: Hypnotics & Sedatives